Francesco Santucci graduated in saxophone at the age of sixteen under the guidance of Alfio Galigani and at the same time studied clarinet and flute. After that he moves to the USA improving further his knowledge under the supervision of Joe Allard in New York and Paul H. Jeffrey at Duke University, Durham. Later his teachers will be: Robert Mann for composition, Lino Quagliero and Bruno Canfora for arrangiament and Francesco de Masi, with whom he will establish a long-term relationship, for orchestra conduction.
During his carreer, playing different musical genders, he collaborated with acknowledged artists, such as: Gunther Schuller, John Faddis, Al Jarreau, Caetano Veloso, Gilberto Gil, Ray Charles, Mel Lewis, Sting and many more, performing in theatres and festivals all around the world. In the field of classical music, he collaborates with Zubin Metha, George Pretre, James Levine and Daniel Harding. Prolific composer, he writes music for cinema and television. In 2011 he won the international music competition of NFA in America. In 2014 one of his compositions won the World Selection for new Compositions for Trumpet, organized by the International Trumpet Guild.
His music has been published by Riverberi Sonori, Beat Records, Pentaflowers, Rai Trade, Rara and BMG. Since 2008 he collaborates with the Conservatories of Nizza, Mentone and Cannes which have introduced his compositions both in the school curriculum and in playing competitions. He teaches saxophone at Saxperience Summer Festival in Herceg Novi, Montenegro. Since 1986 he is the 1st sax Alto, clarinet and flute in the Orchestra di Musica Leggera of RAI Italian Radio and Television Broadcasting Company.